Drug Repurposing for Alzheimer’s Disease Based on Protein-Protein Interaction Network

Table 2

The CMAP analysis on potential candidate drugs.

Drug	Degree	Genes	Up- or downregulated genes
Tamoxifen	7	TGFB1, NTRK1, AR, TP53, ESR1, ESR2, VDR	TP53-up
Raloxifene	7	IL1B, TP53, ESR1, ESR2, VDR, AR, PPARG	AR-up
Haloperidol	6	SLC6A3, SLC6A4, BDNF, LDLR, AR, TP53	LDLR-up; TP53-up
Doxorubicin	5	TGFB1, GSTP1, NTRK2, BDNF	TGFB1-up
Verapamil	5	TGFB1, SLC6A4, GSTP1, LDLR, IL1B	—
Progesterone	5	TARDBP, AR, TP53, ESR1, ESR2	TP53-up
Clozapine	4	SLC6A3, SLC6A4, GSTP1, NTRK2	GSTP1-down
Estradiol	4	AR, ESR1, ESR2, PPARG	AR-up; ESR1-up; ESR2-up
Pilocarpine	4	NTRK2, NTRK1, NTF3, BDNF	—