Protective Effects of Aminooxyacetic Acid on Colitis Induced in Mice with Dextran Sulfate Sodium

Figure 5

AOAA reprograms M1 macrophage differentiation towards M2 macrophages. (a) AOAA reduced M1 macrophage phenotype and reciprocally increased M2 macrophage phenotype in vivo. (b) Statistics of cell populations from (a). The mRNA expression of (c) CD80, (d) CD206, and (e) Arg1. (f) AOAA reversed the effect of LPS on M1 macrophage differentiation. (g) Statistics of cell populations from (f). The mRNA expression of (h) CD80 and (i) iNOS from cells in (f). In (a–e), data are presented as () and one representative experiment of three is shown (^# vs. the H₂O+PBS group; and vs. the DSS+PBS group.) In (f–i), data are presented as of three independent repeats (^# vs. the untreated cell group; and vs. the LPS-stimulated group).

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