Research Article
Multiple Biomarker-Combined Screening for Colorectal Cancer Based on Bisulfate Conversion-Free Detection of Fecal DNA Methylation
Table 5
Sensitivity and specificity of methylated stool DNA among subgroups.
| | Different groups | SDC2 | SEPT9 | SFRP2 | NDRG4 | BMP3 | Combination# |
| | CRC () | No. of positive results | 116 | 159 | 106 | 124 | 6 | 170 | | Sensitivity (%) | 64.44% | 88.33% | 58.89% | 68.89% | 3.33% | 94.44% | | Adenoma () | No. of positive results | 11 | 21 | 15 | 23 | 1 | 23 | | Sensitivity (%) | 18.33% | 35% | 25% | 38.33% | 1.66% | 38.33% | | Polyp () | No. of positive results | 9 | 41 | 5 | 55 | 1 | 56 | | Specificity (%) | 96.7% | 84.98% | 98.17% | 79.85% | 99.63% | 79.49% | | Normal () | No. of positive results | 25 | 81 | 20 | 83 | 2 | 84 | | Specificity (%) | 96.03% | 87.12% | 96.82% | 86.8% | 99.68% | 86.65% |
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#Combination: positive methylation of at least one of the five markers (five markers were used in the model: ) was considered high risk for CRC. |
