Development and Evaluation of Nomograms to Predict the Cancer-Specific Mortality and Overall Mortality of Patients with Hepatocellular Carcinoma

Table 2

Univariable and multivariable analyses of cancer-specific survival.

Cancer-specific survival (competing risk)
Characteristic	Univariable		Multivariable
	SHR (95% CI)	value	SHR (95% CI)	value
Age (years)	1.002 (1.001-1.003)	<0.001	1.000 (0.997-1.003)	0.986
Sex
0 (female)	1		1
1 (male)	1.154 (1.119-1.191)	<0.001	1.132 (1.046-1.225)	0.002
Race
1 (white)	1		1
2 (black)	1.183 (1.139-1.228)	<0.001	1.059 (0.964-1.164)	0.230
3 (others)	0.906 (0.876-0.938)	<0.001	0.959 (0.880-1.046)	0.345
Grade
Low	1		1
High	1854 (1.765-1.948)	<0.001	1.757 (1.631-1.892)	<0.001
Tumor size
<5 mm	1		1
≥5 mm	3.014 (2.926-3.105)	<0.001	1.577 (1.459-1.705)	<0.001
Lymphatic metastasis
No	1		1
Yes	2.001 (1.935-2.068)	<0.001	1.220 (1.087-1.368)	<0.001
Distant metastasis
No	1		1
Yes	3.559 (3.436-3.686)	<0.001	1.550 (1.398-1.718)	<0.001
Stage
Early	1		1
Advanced	3.651 (3.543-3.762)	<0.001	1.760 (1.614-1.918)	<0.001
Surgery (yes:1, no: 0)
No	1		1
Yes	0.263 (0.254-0.273)	<0.001	0.295 (0.274-0.319)	<0.001
Radiotherapy
No	1		1
Yes	1.286 (1.222-1.354)	<0.001	0.808 (0.716-0.912)	<0.001
Insurance
No	1		1
Yes	0.537 (0.501-0.576)	<0.001	0.670 (0.567-0.791)	<0.001
Marriage
No	1		1
Yes	0.825 (0.804-0.847)	<0.001	0.866 (0.809-0.927)	<0.001

HR: hazard ratio; CI: confidence interval. .