Screening of Altered Metabolites and Metabolic Pathways in Celiac Disease Using NMR Spectroscopy
Table 3
Significant pathway based on values/FDR.
Pathway name
Totala
Hitsb
FDR
Impactc
1
Aminoacyl-tRNA biosynthesis
48
7
4.058-6
5.3917
3.4087-4
0.16667
2
Primary bile acid biosynthesis
46
6
4.4108-5
4.3555
0.0018525
0.07433
3
Nitrogen metabolism
6
2
0.0033199
2.4789
0.069718
0.0
4
D-Glutamine and D-glutamate metabolism
6
2
0.0033199
2.4789
0.069718
0.5
5
Valine, leucine, and isoleucine biosynthesis
8
2
0.0060807
2.216
0.08513
0.0
6
Taurine and hypotaurine metabolism
8
2
0.0060807
2.216
0.08513
0.42857
7
Glyoxylate and dicarboxylate metabolism
32
3
0.012055
1.9188
0.13782
0.04233
8
Glycine, serine, and threonine metabolism
33
3
0.013126
1.8819
0.13782
0.26741
9
Arginine biosynthesis
14
2
0.018672
1.7288
0.17427
0.11675
Abbreviations: FDR: false discovery rate. aThe total number of metabolites in each pathway. bThe number of identified metabolites in each pathway. cThe pathway impact is based on scores from topology analysis.
