Role of SNPs in the Biogenesis of Mature miRNAs

Figure 6

Distribution of pre-miRNAs between nor-pre-miRNA and iso-pre-miRNA based on SNP location in pre-miRNA. The SNP location in pre-miRNA includes five sections which were defined in Figure 4. In (a), pre-miRNA in which P5_5 site is changed or not by SNP effect is named P5_5-associated pre-miRNA. The pre-miRNA which site is abnormally processed is named iso-pre-miRNA. The pre-miRNA which site is normally processed is named nor-pre-miRNA.

(a) The section of P5_5-associated pre-miRNAs

(b) The section of P5_3-associated pre-miRNAs

(c) The section of P3_5-associated pre-miRNAs

(d) The section of P3_3-associated pre-miRNAs