Differential Gene Expression in Bladder Tumors from Workers Occupationally Exposed to Arylamines

Table 2

Dose-response relationship between gene expression and arylamine exposure level, within the 21 differentially expressed genes between arylamine-exposed and unexposed cases using PanCancer Progression Panel and Custom panel with an FDR value cutoff of 0.05. The arylamine-exposed cases are subcategorized into three exposure groups: Group 1 with exposure score under 332, Group 2 with exposure scores from 333 to 554, and Group 3 with exposure scores over 554. Mean normalized expression values are shown along with SD (standard deviation) values.

(a)

PanCancer Progression Panel
Gene					Coef
	Unexposed group; ()	Exposure group 1; ()	Exposure group 2; ()	Exposure group 3; ()
CD46					0.436		0.014
NR4A1					-0.899		0.017

(b)

Custom panel
Gene					Coef
	Unexposed group; ()	Exposure group 1; ()	Exposure group 2; ()	Exposure group 3; ()
BAX					-0.485		0.048
YWHAZ					-0.377		0.048