Research Article
Development of a Population Pharmacokinetic Model for Cyclosporine from Therapeutic Drug Monitoring Data
| | Parameter | Mean | RSE (%) | Description |
| | Tlag (h) | 0.512 | 8.48 | Latency time | | Ka (h-1) | 0.523 | 8.54 | Absorption constant | | Cl/F (L/h) | 30.3 | 8.25 | Apparent clearance | | βCL-CLCr | -0.204 | 43.7 | | | Q/F (L/h) | 17.0 | 12.1 | Apparent clearance of distribution | | V1 (L) | 17.9 | 17.6 | Apparent volume of central compartment | | V2 (L) | 400 | 45.6 | Apparent volume of peripheral compartment | | IIV Cl (%) | 39.8 | 16.6 | Interindividual variability of Cl | | IIV Q (%) | 53.2 | 18.7 | Interindividual variability of Q | | IOV Cl (%) | 38.0 | 8.53 | Interoccasion variability of Cl | | IOV tlag (%) | 54.1 | 12.4 | Interoccasion variability of tlag | | IOV ka (%) | 52.6 | 9.85 | Interoccasion variability of ka | | Ka-Cl | -0.551 | 20.2 | Correlation between Ka-Cl | | Prop (%) | 0.228 | 8.86 | Proportional error | | Add (ng/mL) | 7.52 | 45.0 | Additive error | | AIC | 6204 | | Akaike information criterion |
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