Vitamin E-Enhanced Liners in Primary Total Hip Arthroplasty: A Systematic Review and Meta-Analysis

Table 1

Baseline information of included studies.

Study	Years	Type of study	Grouping	Sample size	Age	Inclusion criteria	Surgery approach	Observation index	Follow-up
Rochcongar et al. [24]	2020	RCT	HXLPE/VitE	33		Primary or secondary osteoarthritis or osteonecrosis	Not reported	Liner wear, femoral head penetration, osteolysis, prosthesis loosening, cup angle, HHS, MAP	5 y
			UHMWPE	29
Kjærgaard et al. [20]	2020	RCT	vE-PE	53	64 (56-67)	Primary osteoarthritis, 40-70 years of age	Posterolateral approach	Liner wear, femoral head penetration, osteolysis, prosthesis loosening, cup angle, HHS, UCLA, EQ-5D, SF-36	5 y
			XLPE	63	62.5 (54-66)
Sköldenberg et al. [16]	2019	RCT	VE	21		Primary osteoarthritis	Posterolateral approach	Liner wear, femoral head penetration, osteolysis, prosthesis loosening, cup angle, bone cement quality, HHS, UCLA, EQ-5D, SF-36	2 y
			ArComXL	21
Busch et al. [21]	2020	RCT	UHMWPE-XE	51	Not reported	Primary osteoarthritis	According to the habit of the surgeon	CAD, liner wear, femoral head penetration, osteolysis, prosthesis loosening, cup angle	5 y
			UHMWPE-X	43
Nebergall et al. [19]	2017	RCT	HXLPE/VitE	32	67 (43-76)	Primary osteoarthritis, 25-75 years of age	Posterolateral approach	Liner wear, femoral head penetration, osteolysis, prosthesis loosening, cup angle, HHS, UCLA, EQ-5D, SF-36, VAS	5 y
			ArComXL	35	65 (40-73)
Scemama et al. [26]	2017	RCT	VE-PE	38	67 (32-74)	Primary or secondary arthritis,	Posterolateral approach	Liner wear, femoral head penetration, osteolysis, prosthesis loosening, cup angle, Merle d’Aubigné hip score	3 y
			UHMWPE	36	66 (49-75)
Galea et al. [17]	2019	RCT	VEPE	44		Primary osteoarthritis, 25-75 years of age	Posterolateral approach	Liner wear, femoral head penetration, osteolysis, prosthesis loosening, cup angle, HHS, UCLA, EQ-5D, SF-36, NRS	7 y
			ModXLPE	45
Rochcongar et al. [23]	2018	RCT	HXLPE/VitE	33		Primary or secondary osteoarthritis or osteonecrosis, 18-75 years of age	Not reported	Liner wear, femoral head penetration, osteolysis, prosthesis loosening, cup angle, HHS, MAP	3 y
			UHMWPE	29
Shareghi et al. [27]	2017	RCT	HXLPE/VitE	38	Not reported	Primary osteoarthritis, 25-75 years of age	Not reported	Femoral head penetration, cup migration, femoral stem migration, HHS	5 y
			ArComXL	29
Van Erp et al. [22]	2020	RCT	HXLPE/VitE	102		Ages 20-85, primary osteoarthritis, osteoarthritis, rheumatoid arthritis, avascular necrosis of the femoral head or trauma	According to the habit of the surgeon	Liner wear, femoral head penetration, osteolysis, prosthesis loosening, cup angle, HHS, NRS	2 y
			UHMWPE	97
Salemyr et al. [25]	2015	RCT	VE-HXLPE	25		Primary osteoarthritis, 40-70 years of age	Posterolateral approach	Liner wear, head penetration, HHS, EQ-5D	2 y
			HXLPE	26
Galea et al. [18]	2018	OS	VEPE	136		Primary osteoarthritis	According to the habit of the surgeon	Liner wear, femoral head penetration, osteolysis, prosthesis loosening, cup angle, HHS, VAS, EQ-5D, SF-36	5 y
			ModXLPE	57
Sillesen et al. [28]	2016	OS	E-XLPE	520	Not reported	Primary or secondary osteoarthritis, 25-75 years of age	Posterolateral approach, direct lateral approach, or direct anterior approach	Liner wear, femoral head penetration, osteolysis, prosthesis loosening, cup angle, HHS, UCLA, EQ-5D, SF-36, VAS	3 y
			ArComXL	457
Hemmilä et al. [29]	2021	OS	VE-HXLPE	2723		Primary hip replacement	According to the habit of the surgeon	Revision, revision for loosening of the cup, osteolysis, liner wear, or liner breakage	5 y
			HXLPE	2707					11 y