Differences of Key Proteins between Apoptosis and Necroptosis

Table 4

The relationship between disease and key proteins.

Key proteins	Effect in disease	Related diseases	FDA-approved inhibitor (company)	References
Caspase-8	Mediator	Inflammation and disease in rodent malaria	None	[52]
RIPK1	Activation of RIPK1	Skin diseases, including melanoma, psoriasis, and systemic lupus erythematosus	Sunitinib (Pfizer), Pazopanib (GSK, Novartis)	[53, 54]
RIPK3	Mediator	Sepsis-associated organ injury and chronic lung diseases	Dabrafenib (GSK, Novartis)	[54, 55]