TRAF6 Promoted Tumor Glycolysis in Non-Small-Cell Lung Cancer by Activating the Akt-HIF<i>α</i> Pathway

<div>TRAF6 mediated tumor glycolysis in NSCLC. (a) TRAF6 shRNAs inhibited tumor glycolysis. After the transfection of TRAF6-shRNA, glucose consumption and lactate production were determined as described. (b) TRAF6 shRNAs suppressed hexokinase-2 expression. In TRAF6-deficient cells, the expression of pivotal proteins in the glucose metabolism pathway was examined. (c) TRAF6 shRNA inhibited hexokinase-2 expression in mitochondria. 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BioMed Research International

fig2

Figure 2

Figure 2: TRAF6 Promoted Tumor Glycolysis in Non-Small-Cell Lung Cancer by Activating the Akt-HIF<i>α</i> Pathway 

BioMed Research International

TRAF6 Promoted Tumor Glycolysis in Non-Small-Cell Lung Cancer by Activating the Akt-HIFα Pathway

Figure 2