Identification of Key Exosome Gene Signature in Mediating Coronary Heart Disease by Weighted Gene Correlation Network Analysis

Figure 4

Construction of weighted gene coexpression network of CHD samples. (a) Sample clustering to detect outliers. (b) The cutoff was set to be 0.9, and was chosen to be the soft-threshold power. (c) The gene dendrogram showed that the molecules were classified into different gene modules based on the correlation analysis. Different colors represented the different modules. (d) A heat map of the relationship between module traits showed the correlation between different modules and disease status. The red square represented a positive correlation, and the blue square represented a negative correlation. The common correlation between the module and the disease and the value was shown in the box. (e) Correlation between module membership of blue and green circles and gene significance (absolute value). (f) Venn diagram of gene crossover between the DEG list and the blue module. A total of 715 overlapping genes were located at the intersection of the DEGs and the blue module. Abbreviation: DEGs: differentially expressed genes.

(a)

(b)

(c)

(d)

(e)

(f)