Identification of Key Exosome Gene Signature in Mediating Coronary Heart Disease by Weighted Gene Correlation Network Analysis

Table 1

GO analysis of overlapping genes.

Category	ID	Description	Adjust- value	Genes
BP	GO:0043312	Neutrophil degranulation	3.25-11	DEFA1B/HSPA1B/CAMP/MPO/AZU1/MMP8/DEFA1/CTSG/PRTN3/PGAM1/MMP9/ELANE/S100A8/HP/EPX/LTF/PRG2/PGLYRP1/CEACAM6/S100A9/CYSTM1/CDA/LYZ/ORM1/FCGR3B/DEFA4/S100A12/BPI/OLFM4/PRG3/LGALS3/RNASE2/HVCN1/A1BG/MS4A3/SLC2A5/ABCA13/HSPA1A/S100P/TNFAIP6/CD59/GPR84/FPR1/ARG1/RNASE3/BRI3/CXCR1/CRISP3/CEACAM8/PRAM1/MME/ALAD/PTGES2
BP	GO:0002283	Neutrophil activation involved in immune response	3.25-11	DEFA1B/HSPA1B/CAMP/MPO/AZU1/MMP8/DEFA1/CTSG/PRTN3/PGAM1/MMP9/ELANE/S100A8/HP/EPX/LTF/PRG2/PGLYRP1/CEACAM6/S100A9/CYSTM1/CDA/LYZ/ORM1/FCGR3B/DEFA4/S100A12/BPI/OLFM4/PRG3/LGALS3/RNASE2/HVCN1/A1BG/MS4A3/SLC2A5/ABCA13/HSPA1A/S100P/TNFAIP6/CD59/GPR84/FPR1/ARG1/RNASE3/BRI3/CXCR1/CRISP3/CEACAM8/PRAM1/MME/ALAD/PTGES2
BP	GO:0050832	Defense response to fungus	4.58-07	DEFA1B/DEFA3/MPO/DEFA1/CTSG/ELANE/S100A8/LTF/S100A9/DEFA4/S100A12/HRG/ARG1
BP	GO:0019730	Antimicrobial humoral response	6.57-07	DEFA1B/CAMP/DEFA3/AZU1/DEFA1/CTSG/PRTN3/ELANE/S100A8/LTF/PGLYRP1/S100A9/LYZ/DEFA4/S100A12/BPI/CXCL9/HRG/BCL3/PGLYRP2/FGB/RNASE3
BP	GO:0031640	Killing of cells of other organism	1.68-06	DEFA1B/CAMP/DEFA3/AZU1/DEFA1/CTSG/ELANE/LTF/PGLYRP1/LYZ/DEFA4/S100A12/HRG/ARG1/APOL1
CC	GO:0034774	Secretory granule lumen	1.77-09	DEFA1B/CAMP/DEFA3/MPO/AZU1/MMP8/DEFA1/CTSG/PRTN3/PGAM1/ELANE/S100A8/HP/EPX/LTF/PGLYRP1/S100A9/CDA/LYZ/ORM1/FN1/DEFA4/S100A12/TIMP3/BPI/OLFM4/PRG3/RNASE2/A1BG/HRG/S100P/FGB/ARG1/RNASE3/APOA1/CRISP3/ALAD/PTGES2
CC	GO:0060205	Cytoplasmic vesicle lumen	1.77-09	DEFA1B/CAMP/DEFA3/MPO/AZU1/MMP8/DEFA1/CTSG/PRTN3/PGAM1/ELANE/S100A8/HP/EPX/LTF/PGLYRP1/S100A9/CDA/LYZ/ORM1/FN1/DEFA4/S100A12/TIMP3/BPI/OLFM4/PRG3/RNASE2/A1BG/HRG/S100P/FGB/ARG1/RNASE3/APOA1/CRISP3/ALAD/PTGES2
CC	GO:0031983	Vesicle lumen	1.77-09	DEFA1B/CAMP/DEFA3/MPO/AZU1/MMP8/DEFA1/CTSG/PRTN3/PGAM1/ELANE/S100A8/HP/EPX/LTF/PGLYRP1/S100A9/CDA/LYZ/ORM1/FN1/DEFA4/S100A12/TIMP3/BPI/OLFM4/PRG3/RNASE2/A1BG/HRG/S100P/FGB/ARG1/RNASE3/APOA1/CRISP3/ALAD/PTGES2
MF	GO:0016209	Antioxidant activity	0.000793131	HBA1/MPO/HBA2/HP/EPX/S100A9/PRDX2/APOE/TXN/HBM/HBZ/TXNDC17/HBG1/PXDNL
MF	GO:0004601	Peroxidase activity	0.002388549	HBA1/MPO/HBA2/EPX/PRDX2/HBM/HBZ/TXNDC17/HBG1/PXDNL
MF	GO:0031720	Haptoglobin binding	0.002388549	HBA1/HBA2/HBM/HBZ/HBG1

Abbreviations: BP: biological process; CC: cellular component; MF: molecular function.