Research Article

Proteome Analysis of the Hypothalamic Arcuate Nucleus in Chronic High-Fat Diet-Induced Obesity

Table 1

GO pathway analysis—biological process.

Term (GO ID)ReferenceObservedExpectedF.E. valueFDR

Negative regulation of protein kinase activity by regulation of protein phosphorylation (0044387)830.0647.78
mRNA catabolic process (0006402)11970.937.49
RNA metabolic process (0016070)1234259.692.58
Nucleic acid metabolic process (0090304)17703413.892.45
Nucleobase-containing compound metabolic process (0006139)21944117.222.38
Organic cyclic compound metabolic process (1901360)26184620.552.24
Organic substance metabolic process (0071704)67078952.641.69
Metabolic process (0008152)72249856.71.73
Cellular nitrogen compound metabolic process (0034641)27914621.912.1
Nitrogen compound metabolic process (0006807)57277944.951.76
Cellular metabolic process (0044237)63399349.751.87
Cellular process (0009987)14067143110.411.3
Heterocycle metabolic process (0046483)23314218.32.3
Cellular aromatic compound metabolic process (0006725)24054118.882.17
Primary metabolic process (0044238)62758849.251.79
Macromolecule metabolic process (0043170)50657039.751.76
Nucleobase-containing compound catabolic process (0034655)234131.847.08
Aromatic compound catabolic process (0019439)292132.295.67
Cellular nitrogen compound catabolic process (0044270)272132.136.09
Organic cyclic compound catabolic process (1901361)323132.545.13
Heterocycle catabolic process (0046700)278132.185.96
Cellular macromolecule metabolic process (0044260)39675831.141.86
rRNA processing (0006364)19991.565.76
Cellular component organization or biogenesis (0071840)52846741.471.62
rRNA metabolic process (0016072)208101.636.13
ncRNA metabolic process (0034660)419153.294.56
ncRNA processing (0034470)343122.694.46
Cellular biosynthetic process (0044249)19843415.572.18
Biosynthetic process (0009058)21573416.932.01
G protein-coupled receptor signaling pathway (0007186)1849014.51<0.01
Sensory perception of chemical stimulus (0007606)122509.61<0.01

GO: Gene Ontology; FDR: false discovery rate; F.E.: fold enrichment.