Proteomic Analysis of Human Serum for Patients at Different Pathological Stages of Hepatic Fibrosis

Table 1

Differential proteome biomarkers identified among early stages of human hepatic fibrosis.

No.	Gene_name	Score	#.Proteins	#.Unique peptides	#.Peptides	value	F1 compared to CON	F2 compared to CON	F1 compared to F2
P1	H2AFJ	0.00000	3	1	1	0.024036062	↓	—	—
P2	KRT1	1101.18878	3	22	26	0.075756699	↓	—	—
P3	ECM1	829.84757	2	20	20	0.070533925	↓	—	—
P4	BLVRB	27.90000	1	1	1	0.094149283	↓	—	—
P5	FLNA	0.00000	3	1	2	0.074369236	↓	—	—
P6	CILP2	32.04	1	1	1	0.09912335	↓	—	—
		32.04000	1	1	1	0.064356888	—	↓	—
P7	SERPINF2	1408.12683	1	25	26	0.052802344	↓	—	—
P8	CFAP70	0.00000	1	1	1	0.072389646	↓	—	—
		0.00000	1	1	1	0.090199296	—	↓	—
P9	OLFM1	85.92000	1	4	4	0.058550382	↑	—	—
P10	SAA4	201.35646	1	10	10	0.006200331	↑	—	—
		201.35646	1	10	10	0.002215994	—	—	↑
P11	RBP4	938.50225	2	23	24	0.034149896	↑	—	—
		938.50225	2	23	24	0.050366617	—	—	↑
P12	CTSZ	25.31000	1	1	1	0.072762411	↑	—	—
P13	TRPV4	30.58000	1	1	1	0.098420076	↑	—	—
P14	FCN2	122.74000	2	5	5	0.022181252	↑	—	—
P15	TRDN	0.00000	1	1	1	0.068395908	↑	—	—
P16	HNRNPCL1	43.77338	7	1	3	0.089950328	↑	—	—
P17	SSC5D	25.92000	4	7	8	0.039565254	↑	—	—
P18	LTF	90.46184	2	6	7	0.06941711	—	—	↓
P19	LRWD1	40.16000	1	1	1	0.072317477	—	—	↓
P20	LGALS3BP	1211.55710	1	23	23	0.073712639	—	—	↓
P21	KRT16	396.14000	19	6	20	0.026026008	—	—	↓
P22	SOD1	36.14000	1	1	1	0.084864486	—	—	↓
P23	HEG1	50.56667	1	3	3	0.026031828	—	—	↓
		50.56667	1	3	3	0.027063278	—	↑	—
P24	LRRC63	0.00000	1	1	1	0.064496929	—	—	↓
P25	PLTP	20.80000	1	4	4	0.025348795	—	—	↑
P26	CTDSP1	0.00000	1	1	1	0.03189535	—	—	↑
P27	CALM2	53.02000	1	1	1	0.034430516	—	—	↑
P28	LMAN2	54.14000	1	1	1	0.025709665	—	—	↑
P29	CAVIN2	17.15000	1	1	1	0.080412212	—	—	↑
P30	ZNHIT6	24.43000	1	1	1	0.076303624	—	—	↑
P31	ZDBF2	0.00000	1	1	1	0.043950877	—	—	↑
P32	STIL	0.00000	1	1	1	0.090414752	—	—	↑
P33	PDLIM5	0.00000	1	1	1	0.064865463	—	—	↑
P34	LPA	247.26695	10	11	15	0.043720414	—	—	↑
P35	ZNF407	0.00000	1	1	1	0.058035207	—	—	↑
P36	TREML1	53.87000	1	1	1	0.045038842	—	—	↑
P37	NCAPH2	0.00000	1	1	1	0.07040615	—	—	↑
		0.00000	1	1	1	0.035792866	—	↓	—
P38	APMAP	111.30000	1	4	4	0.015403975	—	—	↑
P39	DHX29	0.00000	1	1	1	0.074446161	—	↓	—
P40	IGFALS	1063.36355	3	29	29	0.046034759	—	↓	—
P41	RBFA	30.10000	1	1	1	0.084658688	—	↓	—
P42	IL1RAP	96.38968	1	4	4	0.081708039	—	↓	—
P43	SCRIB	42.63000	1	1	1	0.075998794	—	↓	—
P44	SERPINA10	265.07827	1	15	15	0.091672136	—	↓	—
P45	CFL1	50.32000	2	2	2	0.001375553	—	↓	—
P46	LRP1	82.42144	4	8	8	0.069375115	—	↑	—
P47	MCAM	122.44266	1	5	5	0.038473214	—	↑	—
P48	GAN	0.00000	1	1	1	0.030673318	—	↑	—
P49	TGOLN2	61.19000	1	3	3	0.01652702	—	↑	—
P50	UMOD	27.61000	1	2	2	0.07475014	—	↑	—
P51	GPI	0.00000	1	2	2	0.087016827	—	↑	—
P52	SPATA5	0.00000	1	1	1	0.048833958	—	↑	—
P53	IGHA1	484.36598	1	6	10	0.048432175	—	↑	—
P54	CRMP1	0.00000	1	1	1	0.048966322	—	↑	—
P55	ORM2	167.79667	1	3	10	0.068257089	—	↑	—

Differential proteome biomarkers were identified by a series of statistical analysis methods. Gene-name: corresponding gene code for identified protein; Score: matching score by identification; .Proteins: number of detected proteins; Unique.Peptides: number of matched unique peptides; Peptides: number of matched peptides; value: <0.1; F1 compared to CON: expression abundance of detected protein in F1 compared to control. ↑ Upregulated (fold ); ↓ downregulated (fold ); — no significant difference.