Proteomic Analysis of Human Serum for Patients at Different Pathological Stages of Hepatic Fibrosis
Table 2
Differential proteome biomarkers identified between F2 and F3 stage of human hepatic fibrosis.
Gene_name
Score
#.Proteins
#.Unique peptides
#.Peptides
MEAN_F2
MEAN_F3
value
Fold change
CDHR2
67.84000
1
3
3
1.1567284
3.734641735
0.030393796
0.309729415
KIF23
28.40000
1
1
1
1.04066865
1.95383209
0.039067086
0.532629521
ZZEF1
25.17000
1
1
1
0.8163386
1.487453045
0.049786133
0.548816383
CDC45
0.00000
1
1
1
1.12066555
1.869070045
0.084625645
0.599584565
RAD54B
40.41000
1
1
2
0.6076129
0.99280659
0.056997498
0.612015378
LAMC1
0.00000
1
1
1
1.1089689
1.772332385
0.022077332
0.625711582
TTLL8
0.00000
1
1
1
4.05722105
6.31038606
0.079588868
0.642943397
SELP
0.00000
1
1
2
0.724277
1.108942335
0.086915236
0.653124132
CDH5
171.82359
4
7
7
1.24961025
1.77250671
0.003952212
0.704996062
PPIA
47.52000
1
2
2
0.7527572
1.065196395
0.00435389
0.706683954
NCAPH2
0.00000
1
1
1
0.71071275
0.99506203
0.03631808
0.714239644
C9orf72
0.00000
1
1
1
0.9843088
1.353627895
0.043848292
0.727163502
CFD
159.69858
1
4
4
1.11917855
1.5199342
0.079326489
0.736333553
HIST1H4A
34.17000
1
2
2
0.868301
1.16223271
0.077412598
0.747097369
LGALS3BP
1211.55710
1
23
23
0.91597945
1.222727335
0.010768933
0.749128137
FUCA2
71.67000
1
2
2
1.2904989
1.719141185
0.024010826
0.750664873
CD109
70.02583
1
2
4
0.6950532
0.916618035
0.072198557
0.758280083
COL1A1
2125.43260
2
57
60
0.99170045
1.24126761
0.011756652
0.798941696
CAT
268.12000
1
10
10
0.88607235
1.090651505
0.057746831
0.812424818
COL1A2
560.04586
3
31
34
1.00269395
1.232292785
0.07134999
0.813681588
LMAN2
54.14000
1
1
1
1.15866175
1.41990701
0.06521473
0.816012416
COL3A1
33.64000
2
1
3
1.04177725
1.265808275
0.098490075
0.823013461
FABP1
59.87000
1
2
2
0.9981057
1.21195429
0.018034945
0.823550614
TNR
24.25000
1
1
1
0.94406445
0.733598025
0.042108231
1.286896117
CPQ
23.83000
1
1
1
1.00661395
0.77643779
0.002213724
1.296451516
IL1RAP
96.38968
1
4
4
0.79807365
0.604451735
0.096536441
1.32032651
UMOD
27.61000
1
2
2
1.1963501
0.89455069
0.010180284
1.337375415
GNPTG
0.00000
1
2
2
1.3583153
1.00752861
0.054291649
1.348165488
CTBS
35.04000
1
3
3
0.85170885
0.629964875
0.083385639
1.351994189
C4A
9942.66108
9
5
179
1.0382126
0.72739336
0.046765794
1.427305578
CNDP1
489.80074
1
16
16
1.0953562
0.726863725
0.088400653
1.506962258
APCS
670.46990
1
9
9
1.0782359
0.625951395
0.092351646
1.722555311
MGA
0.00000
1
1
1
0.8007978
0.464695475
0.050165383
1.723274366
LTF
90.46184
2
6
7
1.31309015
0.7046773
0.074555121
1.863392151
ANKHD1
27.69000
2
1
2
0.84187635
0.43930618
0.090521544
1.916377206
LRWD1
40.16000
1
1
1
1.25997445
0.529221705
0.005758134
2.380806452
ORM2
167.79667
1
3
10
1.91838385
0.796487075
0.085053393
2.408556159
MYH10
0.00000
1
1
1
0.5197956
0.20681813
0.014314988
2.513298036
SERPINE1
54.42000
1
1
1
0.7277185
0.28168128
0.013278244
2.583481941
ATXN2
0.00000
1
1
1
0.51939755
0.13630007
0.086563626
3.810691733
TUFM
0.00000
1
1
1
0.44915935
0.09972096
0.094500863
4.504161913
Differential proteome biomarkers were identified by a series of statistical analysis methods. Gene-name: corresponding gene code for identified protein; Score: matching score by identification; .Proteins: number of detected proteins; Unique.Peptides: number of matched unique peptides; Peptides: number of matched peptides; value: <0.1; MEAN-F2: average expression abundance of two biological replicates in F2 group; MEAN-F3: average expression abundance of two biological replicates in F3 group. Upregulated (fold ); downregulated (fold ).
