Proteomic Analysis of Human Serum for Patients at Different Pathological Stages of Hepatic Fibrosis
Table 3
Differential proteome biomarkers identified between F3 and F4 stage of human hepatic fibrosis.
Gene_name
Score
#.Proteins
#.Unique peptides
#.Peptides
MEAN_F3
MEAN_F4
value
Fold change
HIST1H2BK
58.78788
18
3
4
0.91694111
4.567607215
0.02275837
0.200748678
PSAP
178.06571
1
2
2
2.21498952
9.866392995
0.081923017
0.224498408
HIST1H3A
30.10000
3
1
1
1.007118065
3.450025825
0.055961473
0.291916095
SERPINE1
54.42000
1
1
1
0.28168128
0.801853925
0.01566317
0.351287524
TALDO1
25.87000
1
1
1
1.1134471
2.436683265
0.01653216
0.456951921
ADRA1D
0.00000
1
1
1
0.448665155
0.90547077
0.040495495
0.495504847
GPI
0.00000
1
2
2
1.136271275
2.27594925
0.047438887
0.499251587
IGLV1-51
49.24000
2
2
2
0.72031513
1.41407929
0.023970467
0.509388077
LDHA
182.13500
3
5
7
0.98430261
1.74136361
0.026047479
0.565248179
JCHAIN
0.00000
1
1
1
0.775689805
1.297338645
0.064848068
0.597908501
CORO1A
52.96000
1
1
1
1.02980141
1.699410955
0.003867435
0.605975504
YWHAZ
53.67000
3
2
2
1.329026125
2.18042104
0.059619436
0.609527289
VASP
21.22000
1
1
1
1.18331832
1.935903255
0.001346437
0.611248686
MGA
0.00000
1
1
1
0.464695475
0.75144601
0.023766465
0.61840168
TPM3
47.11000
3
1
2
1.07130211
1.66324595
0.06686543
0.644103243
SOD3
55.11000
1
3
3
0.349465775
0.529788505
0.013630205
0.659632611
LCP1
264.31215
3
15
16
0.94516355
1.427876255
0.076290676
0.661936598
LSAMP
31.17000
1
2
2
1.10493157
1.64859985
0.097795998
0.670224233
OR5A2
28.86000
1
1
1
0.52274932
0.7628278
0.066462212
0.685278276
TRDN
0.00000
1
1
1
1.389876265
1.974410795
0.069478636
0.703944827
TIE1
40.70000
1
2
2
1.103988345
1.51950628
0.041233163
0.726544115
CDH2
0.00000
1
2
2
1.199460695
1.59554698
0.038173559
0.751755172
CCDC137
0.00000
1
1
1
0.815490835
1.07219904
0.081920717
0.760577845
LARS
0.00000
1
2
2
1.0754855
1.33752222
0.020995556
0.80408795
AHSG
6661.90805
1
47
47
0.956198385
0.752478425
0.02549769
1.270731962
CDH5
171.82359
4
7
7
1.77250671
1.38291291
0.038095089
1.281719693
FGL2
0.00000
1
1
1
1.271405835
0.98971743
0.059754514
1.284614978
CARD6
0.00000
1
1
1
0.75718159
0.58356132
0.076205764
1.297518468
SERPINF2
1408.12683
1
25
26
0.92664857
0.710921615
0.082596355
1.303446893
IL6ST
24.33000
1
1
1
1.46089552
1.09962861
0.055202499
1.328535386
SERPING1
3869.86349
2
49
49
1.05476914
0.788823005
0.041773876
1.337142975
PARD3
0.00000
1
1
1
0.825738295
0.609493725
0.099038026
1.354793759
PODXL
0.00000
1
2
2
1.4057577
1.028178575
0.091751521
1.367231077
KNG1
8235.22033
1
89
90
1.04430991
0.75566476
0.09603675
1.381975137
CDKL1
0.00000
2
1
1
1.25846535
0.85403005
0.098225782
1.473560971
FUCA2
71.67000
1
2
2
1.719141185
1.132890385
0.015356564
1.517482369
CADM1
93.80667
1
1
1
1.30906101
0.843302865
0.097176886
1.552302339
CFD
159.69858
1
4
4
1.5199342
0.93293038
0.060805301
1.629204314
IGHG4
234.37444
1
1
6
1.206264895
0.680698885
0.066048639
1.772097651
PSMC2
60.25782
9
1
2
0.8917285
0.494511585
0.033185676
1.803250979
RPGR
0.00000
1
1
1
0.718604715
0.382276295
0.044101616
1.87980454
CFHR1
573.43387
1
3
18
1.124351305
0.57180219
0.043641926
1.966329134
TBX18
0.00000
1
1
1
0.60035456
0.288173085
0.072236041
2.083312395
CDHR2
67.84000
1
3
3
3.734641735
1.776737215
0.096422533
2.101966292
ZNF407
0.00000
1
1
1
0.455257525
0.17873621
0.07633917
2.547091745
ATXN2
0.00000
1
1
1
0.13630007
0.03008251
0.079890987
4.530874252
Differential proteome biomarkers were identified by a series of statistical analysis methods. Gene-name: corresponding gene code for identified protein; Score: matching score by identification; .Proteins: number of detected proteins; Unique.Peptides: number of matched unique peptides; Peptides: number of matched peptides; value: <0.1; MEAN-F3: average expression abundance of two biological replicates in F3 group; MEAN-F4: average expression abundance of two biological replicates in F4 group. Upregulated (fold ); downregulated (fold ).
