Development of a 15-Gene Signature Model as a Prognostic Tool in Sex Hormone-Dependent Cancers

Figure 4

Weighted gene coexpression network analysis of luminal A versus other subtypes of BRCA (HER2 overexpressing with ER- and PR-negative or triple-negative BRCA). (a) The correlation between gene modules and luminal A BRCA. (b) The correlation between module membership and gene significance in the turquoise module. (c) Enriched gene ontology functions of the turquoise module. (d) Assessment of the preservation of the turquoise module. The statistical significance of seven module preservation statistics for 8 types of cancer. The module is considered to be preserved if all statistics had a permutation test value < 0.01.

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