Formulation, Optimization, In Vitro and In Vivo Evaluation of Saxagliptin-Loaded Lipospheres for an Improved Pharmacokinetic Behavior

Figure 1

3D response surface plots indicating the collective effect of behenic acid () plus T-80 () on percent yield (a), behenic acid () plus stirring speed () on percent yield (b), T-80 () plus stirring speed () on percent yield (c), behenic acid () plus T-80 () on entrapment efficiency (d), behenic acid () plus stirring speed () on entrapment efficiency (e), T-80 () plus stirring speed () on entrapment efficiency (f), behenic acid () plus T-80 () on drug release at 12 h (g), behenic acid () plus stirring speed () on drug release at 12 h (h), and T-80 () plus stirring speed () on drug release at 12 h (i).

(a)

(b)

(c)

(d)

(e)

(f)

(g)

(h)

(i)