Formulation, Optimization, In Vitro and In Vivo Evaluation of Saxagliptin-Loaded Lipospheres for an Improved Pharmacokinetic Behavior

Table 4

Composition, predicted versus observed results, size, zeta potential, desirability factor, and prediction errors (PE) of optimized lipospheres formulation.

OL composition		Response	Observed value	Predicted value	PE	Desirability	Size (μm)	ZP (mv)
BA (%)	2.5	PY	80	82	3.49	0.993
T-80 (%)	1.5	EE	78	80	4.91	0.936
SS (rpm)	3500	SG-Rel	40	38.5	4.52	0.745

SS: stirring speed; Rel: release; EE: entrapment efficiency; OL: optimized lipospheres; PE: prediction error; ZP: zeta potential.