Research Article
Relationship between Urinary AD7c-NTP with Cerebral Microbleeds Based on APOE Genotype
Table 1
Demographics and clinical characteristics of all participants.
| | No CMBs () | CMBs | All CMBs () | Lobar CMBs () | Deep CMBs () |
| Age at MRI, mean (SD) | 72 (5.4) | 74 (6.2) | 74 (5.1) | 75 (6.7) | Men, (%) | 168 (47.8) | 48 (53.3) | 30 (55.5) | 18 (47.3) | MOCA (median (IQR)) | 27 (24-29) | 27 (25-29)a | 26 (23-29)b | 27 (25-29)c | NIHSS (median (IQR)) | 9 (6-15) | 9 (7-14) | 9 (6-15) | 9 (7-16) | Infarct volume (cm3), mean (SD) | 8.5 (2.1) | 8.0 (2.2) | 8.2 (1.9) | 7.8 (2.3) | SBP (mmHg), mean (SD) | 130 (19) | 135 (20) | 133 (17) | 139 (19) | Diabetes mellitus, (%) | 65 (18.5) | 17 (18.5) | 10 (18.5) | 5 (13.2) | HDL cholesterol (mg/dl) | 56 (16) | 52 (18) | 48 (17) | 54 (19) | LDL cholesterol (mg/dl) | 131 (33) | 140 (36) | 138 (37) | 142 (35) | Current smokers, (%) | 24 (6.8) | 7 (7.6) | 5 (9.2) | 3 (7.9) | Alcohol, (%) | 43 (12.2) | 13 (14.1) | 9 (16.7) | 7 (18.4) | Hypertension, (%) | 172 (48.9) | 58 (63.0)▲ | 31 (57.4) | 28 (73.8)▲▲ | Hypertension treatment, (%) | 140 (81.4) | 45 (77.5) | 23 (74.2) | 22 (78.6) | Aspirin use, (%) | 200 (56.8) | 60 (65.2) | 36 (66.6) | 22 (57.9) | Anticoagulant use, (%) | 7 (1.9) | 3 (3.3) | 1 (1.8) | 2 (5.2) | Thrombolysis treatment | 45 (12.7) | 12 (13.0) | 8 (14.8) | 6 (15.7) | Statin use, (%) | 140 (39.8) | 40 (43.5) | 23 (42.6) | 17 (44.7) | TOAST (%) | LAA | 181 (51.4) | 38 (41.3) | 23 (42.5) | 15 (39.5) | CE | 8 (3.0) | 3 (4.3) | 2 (4.1) | 1 (5.0) | SAD | 120 (45.5) | 37 (53.6) | 26 (53.0) | 11 (55.0) | APOE status, (%) | ε3/ε3, (%) | 270 (76.6) | 59 (64.1) | 34 (62.9) | 25 (65.8) | ε2/ε2, ε2/ε3, ε2/ε4, ε3/ε4, ε4/ε4, (%) | 82 (23.4) | 33 (35.9) | 20 (37.1) | 13 (34.2) | AD7c-NTP (ng/dl), mean (SD) | 1.05 (1.0) | 1.21 (1.08)a | 1.30 (1.11)b | 1.08 (1.03)c |
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MOCA: a, ; b, ; c, . APOE status: , ; , ; , . AD7c-NTP: a, ; b, ; ct, . Hypertension (total CMBs vs. nCMBs): ▲, . Hypertension (lobar CMBs vs. deep CMBs): ▲▲, . LAA: large artery atherosclerosis; CE: cardiogenic brain embolism; SAD: small artery disease; APOE: apolipoprotein E; NIHSS: National Institutes of Health stroke scale. |