Research Article

Relationship between Urinary AD7c-NTP with Cerebral Microbleeds Based on APOE Genotype

Table 1

Demographics and clinical characteristics of all participants.

No CMBs ()CMBs
All CMBs ()Lobar CMBs ()Deep CMBs ()

Age at MRI, mean (SD)72 (5.4)74 (6.2)74 (5.1)75 (6.7)
Men, (%)168 (47.8)48 (53.3)30 (55.5)18 (47.3)
MOCA (median (IQR))27 (24-29)27 (25-29)a26 (23-29)b27 (25-29)c
NIHSS (median (IQR))9 (6-15)9 (7-14)9 (6-15)9 (7-16)
Infarct volume (cm3), mean (SD)8.5 (2.1)8.0 (2.2)8.2 (1.9)7.8 (2.3)
SBP (mmHg), mean (SD)130 (19)135 (20)133 (17)139 (19)
Diabetes mellitus, (%)65 (18.5)17 (18.5)10 (18.5)5 (13.2)
HDL cholesterol (mg/dl)56 (16)52 (18)48 (17)54 (19)
LDL cholesterol (mg/dl)131 (33)140 (36)138 (37)142 (35)
Current smokers, (%)24 (6.8)7 (7.6)5 (9.2)3 (7.9)
Alcohol, (%)43 (12.2)13 (14.1)9 (16.7)7 (18.4)
Hypertension, (%)172 (48.9)58 (63.0)31 (57.4)28 (73.8)▲▲
Hypertension treatment, (%)140 (81.4)45 (77.5)23 (74.2)22 (78.6)
Aspirin use, (%)200 (56.8)60 (65.2)36 (66.6)22 (57.9)
Anticoagulant use, (%)7 (1.9)3 (3.3)1 (1.8)2 (5.2)
Thrombolysis treatment45 (12.7)12 (13.0)8 (14.8)6 (15.7)
Statin use, (%)140 (39.8)40 (43.5)23 (42.6)17 (44.7)
TOAST (%)
 LAA181 (51.4)38 (41.3)23 (42.5)15 (39.5)
 CE8 (3.0)3 (4.3)2 (4.1)1 (5.0)
 SAD120 (45.5)37 (53.6)26 (53.0)11 (55.0)
APOE status, (%)
ε3/ε3, (%)270 (76.6)59 (64.1)34 (62.9)25 (65.8)
ε2/ε2, ε2/ε3, ε2/ε4, ε3/ε4, ε4/ε4, (%)82 (23.4)33 (35.9)20 (37.1)13 (34.2)
AD7c-NTP (ng/dl), mean (SD)1.05 (1.0)1.21 (1.08)a1.30 (1.11)b1.08 (1.03)c

MOCA: a, ; b, ; c, . APOE status: , ; , ; , . AD7c-NTP: a, ; b, ; ct, . Hypertension (total CMBs vs. nCMBs): , . Hypertension (lobar CMBs vs. deep CMBs): ▲▲, . LAA: large artery atherosclerosis; CE: cardiogenic brain embolism; SAD: small artery disease; APOE: apolipoprotein E; NIHSS: National Institutes of Health stroke scale.