Research Article

Relationship between Urinary AD7c-NTP with Cerebral Microbleeds Based on APOE Genotype

Table 2

Interaction between APOE genotype and AD7c-NTP levels in the presence of CMBs.

ModelAPOEUrine AD7c-NTPInteraction
OR (95% CI)

Total CMBs
133590.84 (0.54-1.31)0.440.49
22, 23, 24, 34, 44331.05 (0.53-1.32)0.68
233590.90 (0.60-1.33)0.600.45
22, 23, 24, 34, 44331.03 (0.94-1.12)0.83
Lobar CMBs
133340.83 (0.40-1.69)0.610.03
22, 23, 24, 34, 44202.20 (1.21-3.97)0.009
233340.92 (0.70-1.19)0.950.01
22, 23, 24, 34, 44202.95 (1.38-6.27)0.005
Deep CMBs
133251.04 (0.95-1.13)0.780.32
22, 23, 24, 34, 44131.63 (0.94-2.7)0.08
233251.05 (0.90-1.22)0.530.20
22, 23, 24, 34, 44131.56 (0.96-2.08)0.07

Odds ratio (OR) of CMBs per standard deviation change in AD7c-NTP ( for women, 1.80 for men). Model 1 adjusted for age and sex. Model 2 adjusted for age, sex, aspirin use, anticoagulant use, statin use, diabetes, APOE status (ε3/ε3 versus ε2/ε2, ε2/ε3, ε2/ε4, ε3/ε4, ε4/ε4), and systolic blood pressure.