Identification and Validation of a Dysregulated miRNA-Associated mRNA Network in Temporal Lobe Epilepsy

Figure 1

(a) The volcano plot of DGEs in TLE based on data from GEO. (b) Biological pathway enrichment analysis of up- and downregulated DEGs with the top 10 enrichment scores. (c) Protein–protein interaction network constructed with the DEGs. Red nodes represent upregulated genes, and blue nodes represent downregulated genes. (d) An integration network of the miRNA-mRNA regulatory network and PPI network. The network consisting of has-miRNA-484, 76 upregulated DEGs, and 80 downregulated DEGs was generated by Cytoscape. The yellow diamond represents has-miRNA-484, red nodes represent upregulated genes, blue nodes represent downregulated genes, and the T-arrow edge represents miRNA-mRNA interactions.

(a)

(b)

(c)

(d)