A Potential miRNA-mRNA Network for Dementia and Hernia Crosstalk

Figure 3

Construction of miRNA-mRNA regulatory networks and single-cell expression profiling. The intersections of 359 muscle-related miRNAs and 30 DE-miRNAs in the miRNA-mRNA network were determined by mapping Wayne plots (a). Volcano plot of intersecting genes (b). Sankey plots showing miRNA-mRNA networks constructed based on the miRWalk3.0 database (c). miR-4451 regulates PI16 and BCAP31 expressions (d). Annotated map of the single cell expression from mouse tissues (e). Pi16 was found to be highly enriched in mesenchymal stem cells (f). Bcap31 was found to be enriched in most cell types (g).