Oridonin Promotes Apoptosis and Restrains the Viability and Migration of Bladder Cancer by Impeding TRPM7 Expression via the ERK and AKT Signaling Pathways

Figure 2

Dose-dependent induction of apoptosis in T24 cells by oridonin. (a, b) Annexin V-FITC- and PI-stained cells were quantified by flow cytometry after the T24 cells were incubated with oridonin (0, 1, 2, or 3 μM). (c–e) p53 and cleaved caspase-3 protein levels in T24 cells were assessed after the cells were incubated with oridonin (0, 1, 2, or 3 μM). (f) BAX mRNA levels in T24 cells incubated with oridonin (0, 1, 2, or 3 μM) were determined. and vs. the untreated control (0 μM).

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