VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction

<div>Lung I/R induced inflammatory response and tissue injury. (a–i) Mouse lung tissue and serum collected from the control and I/R groups for the following experiments. (a) Transmission electron microscopy to evaluate ultrastructural changes: microvilli (yellow arrow), mitochondria (blue arrow), and nucleus (green arrow). Scale bar, 5 <i>μ</i>m. (b) Evaluation of pathology by H&amp;E staining. Scale bar, 100 <i>μ</i>m. (c) Lung injury score based on H&amp;E images. (d) IL-6 mRNA levels measured by RT-qPCR. (e, f) IL-6 levels in the lung and serum measured by ELISA. (g) TNF-<i>α</i> mRNA levels measured by RT-qPCR. (h, i) TNF-<i>α</i> level in the lung and serum measured by ELISA. 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BioMed Research International

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Figure 1

Figure 1: VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction 

Figure 1 | VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction 