VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction

<div>OGD/R-induced endothelial barrier disruption and cell injury. (a–g) PMVECs and supernatant were collected from the control and OGD/R groups for the following experiments. (a) Viability of PMVECs assessed by CCK-8. (b, c) IL-6 and TNF-<i>α</i> mRNA levels measured by RT-qPCR. (d, e) IL-6 and TNF-<i>α</i> protein levels in cell supernatant measured by ELISA. (f, g) Immunofluorescence micrographs of PMVEC ZO-1 and VE-cadherin (red) identified by immunofluorescence. DAPI was used to stain the cell nuclei. Scale bar, 200 <i>μ</i>m. 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BioMed Research International

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Figure 2

Figure 2: VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction 

Figure 2 | VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction 