VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction

<div>The effects of caspase-1 inhibitor VX765 on lung injury and inflammation. (a–h) Mouse lung tissue and serum were collected from each group for the following experiments. (a) The pathology score was evaluated by H&amp;E staining. Scale bar, 100 <i>μ</i>m. (b) Lung damage was evaluated based on H&amp;E images. (c) IL-6 mRNA levels measured by RT-qPCR. (d, e) IL-6 protein levels measured in lung and serum by ELISA. (f) TNF-<i>α</i> mRNA level measured by RT-qPCR. (g, h) TNF-<i>α</i> protein level in lung and serum measured by ELISA. 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BioMed Research International

fig5

Figure 5

Figure 5: VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction 

Figure 5 | VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction 