VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction

<div>VX765 treatment attenuated injury and endothelial barrier function in vitro. (a–g) PMVECs and supernatant were collected from each group for the following experiments. (a) Viability of PMVECs assessed by CCK-8. (b, c) IL-6 and TNF-<i>α</i> mRNA levels measured by RT-qPCR. (d, e) IL-6 and TNF-<i>α</i> protein levels in the cell supernatants measured by ELISA. (f, g) Immunofluorescence micrographs of PMVEC ZO-1 (red) and VE-cadherin (red). DAPI was used to stain the cell nuclei. Scale bar, 200 <i>μ</i>m. 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BioMed Research International

fig6

Figure 6

Figure 6: VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction 

Figure 6 | VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction 