VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction

<div>Schematic model of the role of VX765 in protecting against lung injury. Lung I/R activates caspase-1 P20 inducing GSDMD-N to form membrane pores, with IL-1<i>β</i> entering the cell through this pore. Endothelial pyroptosis causes barrier dysfunction leading to lung injury. However, VX765 can alleviate these phenomena.</div>

BioMed Research International

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Figure 9

Figure 9: VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction 

Figure 9 | VX765, a Specific Caspase-1 Inhibitor, Alleviates Lung Ischemia Reperfusion Injury by Suppressing Endothelial Pyroptosis and Barrier Dysfunction 