Research Article

Design and Optimization of Cationic Nanocapsules for Topical Delivery of Tretinoin: Application of the Box-Behnken Design, In Vitro Evaluation, and Ex Vivo Skin Deposition Study

Table 8

Physicochemical properties of the encapsulated TTN (TTN-LCNC), blank gel (HG-B), nonencapsulated TTN gel (HG-TTN), nanocapsule non-TTN gel (HG-LCNC), and encapsulated TTN gel (HG-TTN-LCNC). Results are shown as ().

FormulationpHDrug content (mg/g)Viscosity (cP)Aspect

TTN-LCNCOpalescent, yellow
HG-B—Transparent, colorless
HG-TTNTransparent, yellow
HG-LCNC—Opalescent, white
HG-TTN-LCNCOpalescent, slightly yellow