Integrative Analysis of Differently Expressed Genes Reveals a 17-Gene Prognosis Signature for Endometrial Carcinoma

Figure 6

Establishing a prognostic gene model in the TCGA cohort. (a) LASSO coefficients profiles of 30 prognostic genes in EC. (b) LASSO regression with tenfold cross-validation obtained 17 prognostic genes using minimum lambda value. (c) 543 patients with EC were divided equally into low-risk group and high-risk group on the basis of the median score calculated by the risk score formula. (d) Lower OS time was observed in the high-risk group of EC patients, in comparison with the low-risk group of EC patients by Kaplan-Meier Plotter analysis. (e) Time-dependent receiver operating characteristic (ROC) analysis to assess the sensitivity and specificity of the prognostic model.

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