Whole Volume Apparent Diffusion Coefficient (ADC) Histogram as a Quantitative Imaging Biomarker to Differentiate Breast Lesions: Correlation with the Ki-67 Proliferation Index

Table 3

Comparison of different parameters of whole volumetric ADC histogram ROC curves in differentiation of subtypes of breast cancer.

(a)

Her-2 status
Parameter	Her-2(-); ()	Her-2(+); ()	AUC	95% CI	Sensitivity (%)	Specificity (%)	Cut-off	value
ADC-10%	0.779	0.872	0.679	0.581~0.767	80.00	49.33	0.771	0.001
ADC-50%	1.093	1.142	0.585	0.485~0.681	46.67	73.33	1.153	0.165
ADC-90%	1.532	1.571	0.590	0.490~0.685	53.33	70.67	1.587	0.135
Skewness	0.554	0.584	0.505	0.406~0.604	16.67	93.33	1.310	0.934
Kurtosis	1.347	1.791	0.570	0.470~0.667	40.00	78.67	2.170	0.277
Entropy	6.672	7.516	0.680	0.582~0.768	90.00	42.67	6.140	0.001

(b)

ER/PR status
Parameter	Luminal; ()	Nonluminal ()	AUC	95% CI	Sensitivity (%)	Specificity (%)	Cut-off	value
ADC-10%	0.785	0.869	0.642	0.543~0.734	100	24.05	0.665	0.020
ADC-50%	1.090	1.159	0.595	0.495~0.689	42.31	78.48	1.202	0.163
ADC-90%	1.521	1.610	0.574	0.530~0.722	42.30	70.89	1.555	0.258
Skewness	0.539	0.636	0.541	0.441~0.639	19.23	92.41	1.260	0.538
Kurtosis	1.412	1.663	0.532	0.432~0.630	26.92	87.34	3.130	0.643
Entropy	6.738	7.445	0.626	0.526~0.718	92.31	39.24	6.090	0.041