Mechanical Stretch Induces Annulus Fibrosus Cell Senescence through Activation of the RhoA/ROCK Pathway

<div>Effect of RhoA/ROCK pathway inhibition on AF cell senescence under mechanical stretch. (a–e) Results of cell proliferation, G0/G1 cell cycle arrest, telomerase activity, and mRNA and protein expression of senescence-associated molecules (p16 and p53), respectively. 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BioMed Research International

fig5

Figure 5

Figure 5: Mechanical Stretch Induces Annulus Fibrosus Cell Senescence through Activation of the RhoA/ROCK Pathway 