Research Article
In Silico Drug Screening Analysis against the Overexpression of PGAM1 Gene in Different Cancer Treatments
Table 2
ADMET profiling, absorption, metabolism, and toxicity-related drug-like parameters of candidate compounds.
| | A. ADMET profiling | | Compounds | N-Nitrosohexamethyleneimine | Subtrifloralactone-K | Kanzonol-N |
| | A. Absorption | | Blood-brain barrier | — | + | — | | Human intestinal absorption | — | + | + | | P-glycoprotein substrate | + | + | — | | B. Metabolism | | CYP450 1A2 inhibitor | — | — | + | | CYP450 2C9 inhibitor | — | — | + | | CYP450 2D6 inhibitor | — | — | — | | CYP450 2C19 inhibitor | — | — | + | | CYP450 3A4 inhibitor | — | — | — | | Distribution | | Subcellular localization | Lysosomes | Mitochondria | Mitochondria | | Toxicity | | AMES toxicity | No | No | No |
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