Association Analysis of LEP Signaling Pathway with Type 2 Diabetes Mellitus in Chinese Han Population from South China

Table 1

Basic information of 23 tagSNPs selected from 15 genes in the LEP signaling pathway.

Gene	Chr	Position_37	SNP	Region	Allele		MAF
					Minor	Major
LEP	7	127882070	rs4731426	Intron 1	G	C	0.202
	7	127881349	rs2167270	5UTR	G	A	0.175
LEPR	1	66063117	rs12405556	Intron 7	G	T	0.153
JAK1	1	65326908	rs17127107	Intron 8	C	G	0.321
	1	65379982	rs10889502	Intron 1	G	C	0.375
JAK2	9	4988761	rs7849191	Intron 2	C	T	0.420
STAT3	17	40507980	rs9891119	Intron 1	A	C	0.357
SHP-2	12	112942353	rs4767860	Intron 14	G	A	0.409
PPARGC1A	4	23815924	rs2970847	Exon 8	T	C	0.204
	4	23797000	rs6821591	3UTR	C	T	0.292
PRKAA1	5	40782239	rs249429	Intron 1	C	T	0.255
	5	40796045	rs3805486	Intron 1	A	G	0.212
PRKAA2	1	57177388	rs1342382	3UTR	T	A	0.252
	1	57108423	rs6588640	5 upstream	A	G	0.168
PRKAB2	1	146626922	rs6937	3UTR	T	C	0.409
	1	146641686	rs3766522	Intron 2	A	T	0.128
PRKAG1	12	49390677	rs10783299	Exon 2	T	C	0.346
PRKAG2	7	151255203	rs5017427	Intron 15	A	G	0.261
	7	151502302	rs9648724	Intron 1	G	A	0.245
PRKAG3	2	219682257	rs645163	3 downstream	C	T	0.416
	2	219687597	rs6436094	3UTR	A	G	0.444
Alpha-MSH	2	25384833	rs6713532	Intron 2	T	C	0.374
NPY	7	24323410	rs16147	5 upstream	T	C	0.332