Association Analysis of LEP Signaling Pathway with Type 2 Diabetes Mellitus in Chinese Han Population from South China

Table 4

Results of association analysis between LEP signaling pathway allele and type2 diabetes.

Gene	SNP	Allele	Nondiabetic controls			T2DM patients			value		OR (95% CI)
			A	a	MAF	A	a	MAF	Observed	Adjusted	Observed	Adjusted
LEP	rs4731426	C/G	1488	620	0.294	1460	674	0.316	0.132	0.141	1.11 (0.97-1.26)	1.11 (0.97-1.26)
	rs2167270	G/A	1630	478	0.227	1599	535	0.251	0.071	0.079	1.14 (0.99-1.31)	1.14 (0.99-1.31)
LEPR	rs12405556	T/G	1775	333	0.158	1802	332	0.156	0.833	0.850	0.98 (0.83-1.16)	0.98 (0.83-1.16)
JAK1	rs17127107	C/G	1454	654	0.310	1451	683	0.320	0.491	0.610	1.05 (0.92-1.20)	1.04 (0.91-1.18)
	rs10889502	C/G	1400	708	0.336	1385	749	0.351	0.310	0.292	1.07 (0.94-1.22)	1.07 (0.94-1.22)
JAK2	rs7849191	C/T	1330	778	0.369	1349	785	0.368	0.932	0.963	0.99 (0.88-1.13)	1.00 (0.88-1.13)
STAT3	rs9891119	A/C	1170	938	0.445	1159	975	0.457	0.431	0.451	1.05 (0.93-1.18)	1.05 (0.93-1.19)
SHP-2	rs4767860	A/G	1401	705	0.335	1390	742	0.348	0.360	0.334	1.06 (0.93-1.21)	1.07 (0.94-1.22)
PPARGC1A	rs2970847	C/T	1604	504	0.239	1623	511	0.239	0.982	0.872	1.00 (0.87-1.15)	1.01 (0.88-1.16)
	rs6821591	T/C	1419	689	0.327	1442	692	0.324	0.863	0.782	0.99 (0.87-1.12)	0.98 (0.86-1.12)
PRKAA1	rs249429	T/C	1654	454	0.215	1652	482	0.226	0.411	0.543	1.06 (0.92-1.23)	1.05 (0.90-1.21)
	rs3805486	A/G	1608	500	0.237	1642	492	0.231	0.614	0.961	0.96 (0.84-1.11)	1.00 (0.86-1.15)
PRKAA2	rs1342382	T/A	1567	541	0.257	1598	536	0.251	0.680	0.721	0.97 (0.84-1.12)	0.97 (0.85-1.12)
	rs6588640	G/A	1567	541	0.257	1611	523	0.245	0.392	0.373	0.94 (0.82-1.08)	0.94 (0.81-1.08)
PRKAB2	rs6937	C/T	1167	941	0.446	1131	1002	0.470	0.123	0.272	1.10 (0.97-1.25)	1.07 (0.95-1.22)
	rs3766522	A/T	1875	233	0.111	1864	270	0.127	0.112	0.241	1.17 (0.97-1.41)	1.12 (0.93-1.36)
	rs10783299	T/C	1114	994	0.472	1152	980	0.460	0.451	0.531	0.95 (0.85-1.08)	0.96 (0.85-1.09)
PRKAG2	rs5017427	G/A	1475	633	0.300	1541	593	0.278	0.112	0.130	0.90 (0.79-1.02)	0.90 (0.79-1.03)
	rs9648724	G/A	1605	503	0.239	1621	511	0.240	0.933	0.990	1.01 (0.87-1.16)	1.00 (0.86-1.16)
PRKAG3	rs645163	C/T	1211	897	0.426	1205	929	0.435	0.521	0.654	1.04 (0.92-1.17)	1.03 (0.91-1.16)
	rs6436094	G/A	1175	933	0.443	1196	938	0.440	0.840	0.992	0.99 (0.88-1.11)	1.00 (0.88-1.13)
Alpha-MSH	rs6713532	C/T	1241	867	0.411	1257	877	0.411	0.982	0.922	1.00 (0.88-1.13)	1.01 (0.89-1.14)
NPY	rs16147	C/T	1343	765	0.363	1382	748	0.351	0.432	0.331	0.95 (0.84-1.08)	0.94 (0.83-1.07)