Association Analysis of LEP Signaling Pathway with Type 2 Diabetes Mellitus in Chinese Han Population from South China

Table 5

Comparison of genotype frequencies between the case group and control group in the LEP signaling pathway.

Gene	SNP	Genotype	Nondiabetic controls	T2DM patients	value
						value
LEP	rs4731426	CC/CG/GG	535/418/101	499/462/106	3.495	0.174
	rs2167270	GG/GA/AA	640/350/64	598/403/66	5.107	0.078
LEPR	rs12405556	TT/TG/GG	747/281/26	763/276/28	0.209	0.901
JAK1	rs17127107	CC/CG/GG	491/472/91	490/471/106	1.065	0.587
	rs10889502	CC/CG/GG	464/472/118	441/503/123	1.594	0.451
JAK2	rs7849191	CC/CT/TT	412/506/136	420509/138	0.021	0.990
STAT3	rs9891119	AA/AC/CC	323/524/207	315/529/223	0.640	0.726
SHP-2	rs4767860	AA/AG/GG	464/473/116	452/486/128	0.844	0.656
PPARGC1A	rs2970847	CC/CT/TT	619/366/69	624/375/68	0.057	0.972
	rs6821591	TT/TC/CC	474/471/109	492/458/117	0.721	0.697
PRKAA1	rs249429	TT/TC/CC	653/348/53	639/374/54	1.018	0.601
	rs3805486	AA/AG/GG	623/362/69	633/376/58	1.218	0.544
PRKAA2	rs1342382	TT/TA/AA	576/415/63	598/402/67	0.663	0.718
	rs6588640	GG/GA/AA	586/395/73	609/393/65	0.832	0.660
PRKAB2	rs6937	CC/CT/TT	316/535/203	285/562/220	2.867	0.238
	rs3766522	AA/AT/TT	832/211/11	812/240/15	2.644	0.267
PRKAG1	rs10783299	TT/TC/CC	290/534/230	308/536/222	0.619	0.734
PRKAG2	rs5017427	GG/GA/AA	520/435/99	561/419/87	2.549	0.280
	rs9648724	GG/GA/AA	605/395/54	610/401/55	0.007	0.996
PRKAG3	rs645163	CC/CT/TT	349/513/192	344/517/206	0.464	0.793
	rs6436094	GG/GA/AA	325/525/204	341/514/212	0.575	0.750
Alpha-MSH	rs6713532	CC/CT/TT	350/541/163	365/527/175	0.845	0.656
NPY	rs16147	CC/CT/TT	449/445/160	442/498/125	7.275	0.026