Association Analysis of LEP Signaling Pathway with Type 2 Diabetes Mellitus in Chinese Han Population from South China

Table 6

Association analysis results under five genetic models in the LEP pathway ().

SNP	Additive		Codominant				Dominant		Recessive		Overdominant
		OR (95% CI)			OR (95% CI)			OR (95% CI)		OR (95% CI)		OR (95% CI)
			1	2	1	2
rs4731426	0.129	1.11 (0.97-1.26)	0.171	0.111	1.19 (0.99-1.42)	1.13 (0.83-1.52)	0.066	1.17 (0.99-1.39)	0.781	1.04 (0.78-1.39)	0.089	1.16 (0.98-1.38)
rs2167270	0.071	1.14 (0.99-1.31)	0.022	0.5933	1.23 (1.03-1.48)	1.10 (0.77-1.58)	0.029	1.21 (1.02-1.44)	0.910	1.02 (0.72-1.45)	0.028	1.22 (1.02-1.46)
rs12405556	0.831	0.98 (0.83-1.16)	0.902	0.871	0.96 (0.79-1.17)	1.05 (0.61-1.82)	0.753	0.97 (0.80-1.17)	0.820	1.07 (0.62-1.83)	0.681	0.96 (0.79-1.16)
rs17127107	0.485	1.05 (0.92-1.20)	0.592	0.361	1.00 (0.84-1.20)	1.17 (0.86-1.59)	0.762	1.03 (0.87-1.22)	0.312	1.17 (0.87-1.57)	0.772	0.97 (0.82-1.16)
rs10889502	0.295	1.07 (0.94-1.22)	0.454	0.391	1.12 (0.94-1.34)	1.10 (0.83-1.46)	0.211	1.12 (0.94-1.33)	0.813	1.03 (0.79-1.35)	0.284	1.10 (0.93-1.30)
rs7849191	0.934	1.00 (0.88-1.13)	0.990	0.952	0.99 (0.82-1.19)	1.00 (0.76-1.31)	0.901	0.99 (0.83-1.18)	0.982	1.00 (0.78-1.29)	0.893	0.99 (0.83-1.17)
rs9891119	0.435	1.05 (0.93-1.19)	0.730	0.573	1.04 (0.85-1.26)	1.10 (0.86-1.41)	0.572	1.05 (0.88-1.27)	0.473	1.08 (0.87-1.34)	0.950	0.99 (0.84-1.18)
rs4767860	0.361	1.06 (0.93-1.21)	0.660	0.591	1.05 (0.88-1.26)	1.13 (0.85-1.50)	0.442	1.07 (0.90-1.27)	0.473	1.10 (0.84-1.44)	0.761	1.03 (0.87-1.22)
rs2970847	0.978	1.00 (0.87-1.15)	0.974	0.910	1.02 (0.85-1.22)	0.98 (0.69-1.39)	0.911	1.01 (0.85-1.20)	0.871	0.97 (0.69-1.37)	0.840	1.02 (0.85-1.22)
rs6821591	0.858	0.99 (0.87-1.12)	0.702	0.690	0.94 (0.78-1.12)	1.03 (0.77-1.38)	0.602	0.96 (0.81-1.13)	0.640	1.07 (0.81-1.41)	0.412	0.93 (0.78-1.11)
rs249429	0.412	1.06 (0.92-1.23)	0.604	0.593	1.10 (0.92-1.32)	1.04 (0.70-1.54)	0.331	1.09 (0.92-1.30)	0.972	1.01 (0.68-1.49)	0.322	1.09 (0.91-1.31)
rs3805486	0.615	0.97 (0.84-1.11)	0.542	0.313	1.02 (0.85-1.23)	0.83 (0.57-1.19)	0.921	0.99 (0.83-1.18)	0.281	0.82 (0.57-1.18)	0.671	1.04 (0.87-1.24)
rs1342382	0.680	0.97 (0.84-1.12)	0.724	0.690	0.93 (0.78-1.12)	1.02 (0.71-1.47)	0.521	0.95 (0.80-1.12)	0.773	1.05 (0.74-1.50)	0.423	0.93 (0.78-1.11)
rs6588640	0.388	0.94 (0.82-1.08)	0.662	0.551	0.96 (0.80-1.15)	0.86 (0.60-1.22)	0.490	0.94 (0.79-1.12)	0.441	0.87 (0.62-1.23)	0.762	0.97 (0.82-1.16)
rs6937	0.122	1.10 (0.97-1.25)	0.240	0.213	1.16 (0.95-1.42)	1.20 (0.94-1.54)	0.095	1.17 (0.97-1.42)	0.433	1.09 (0.88-1.35)	0.380	1.08 (0.91-1.28)
rs3766522	0.105	1.17 (0.97-1.41)	0.272	0.431	1.17 (0.95-1.44)	1.40 (0.64-3.06)	0.121	1.18 (0.96-1.44)	0.450	1.35 (0.62-2.96)	0.161	1.16 (0.94-1.43)
rs10783299	0.455	0.96 (0.85-1.08)	0.752	0.443	0.95 (0.77-1.15)	0.91 (0.72-1.17)	0.494	0.94 (0.77-1.13)	0.631	0.95 (0.77-1.17)	0.841	0.98 (0.83-1.17)
rs5017427	0.111	0.90 (0.79-1.03)	0.282	0.221	0.89 (0.75-1.07)	0.81 (0.60-1.11)	0.140	0.88 (0.74-1.04)	0.310	0.86 (0.63-1.16)	0.352	0.92 (0.77-1.09)
rs9648724	0.934	1.01 (0.87-1.16)	1.011	0.982	1.01 (0.84-1.20)	1.01 (0.68-1.49)	0.930	1.01 (0.85-1.20)	0.972	1.01 (0.69-1.48)	0.954	1.01 (0.84-1.20)
rs645163	0.521	1.04 (0.92-1.17)	0.791	0.541	1.02 (0.84-1.24)	1.09 (0.85-1.39)	0.670	1.04 (0.87-1.25)	0.521	1.07 (0.86-1.34)	0.921	0.99 (0.84-1.18)
rs6436094	0.842	0.99 (0.88-1.12)	0.75	0.814	0.93 (0.77-1.13)	0.99 (0.78-1.27)	0.583	0.95 (0.79-1.14)	0.773	1.03 (0.83-1.28)	0.450	0.94 (0.79-1.11)
rs6713532	0.983	1.00 (0.88-1.13)	0.664	0.583	0.93 (0.77-1.13)	1.03 (0.79-1.33)	0.631	0.96 (0.80-1.14)	0.564	1.07 (0.85-1.35)	0.373	0.93 (0.78-1.10)
rs16147	0.433	0.95 (0.84-1.08)	0.172	0.092	1.14 (0.95-1.37)	0.79 (0.61-1.04)	0.611	1.05 (0.88-1.24)	0.020	0.74 (0.58-0.96)	0.035	1.20 (1.01-1.43)

Under the codominance model of rs2167270, the OR of genotype GA relative to GG is 1.23, 95% CI is (1.03-1.48), and ; under the dominant model, the OR of genotype GA-AA relative to GG is 1.21, 95% CI is (1.02-1.44), and ; in the superdominant model, the OR of genotype GA relative to AA-GG is 1.22, 95% CI is (1.02-1.46), and . In the recessive model of rs16147, the OR of genotype TT relative to CC-CT is 0.74, 95% CI is (0.58-0.96), and , relative to CC-CT genotype; TT genotype is a protective factor; under the superdominant model, the OR of genotype CT relative to TT-CC was 1.20, 95% CI was (1.01-1.43), and .