Association Analysis of LEP Signaling Pathway with Type 2 Diabetes Mellitus in Chinese Han Population from South China

Table 8

Results of adjusting covariates under five genetic models in the LEP pathway.

SNP	Additive		Codominant				Dominant		Recessive		Overdominant
		OR (95% CI)			OR (95% CI)			OR (95% CI)		OR (95% CI)		OR (95% CI)
			1	2	1	2
rs4731426	0.192	1.09 (0.96-1.25)	0.210	0.171	1.18 (0.98-1.41)	1.14 (0.84-1.54)	0.081	1.17 (0.98-1.39)	0.724	1.05 (0.79-1.41)	0.124	1.15 (0.96-1.37)
rs2167270	0.118	1.12 (0.97-1.29)	0.024	0.110	1.22 (1.01-1.47)	1.12 (0.78-1.63)	0.039	1.20 (1.01-1.44)	0.822	1.04 (0.72-1.50)	0.044	1.21 (1.00-1.45)
rs12405556	0.874	0.99 (0.83-1.17)	0.970	0.920	0.97 (0.80-1.19)	1.01 (0.58-1.76)	0.810	0.98 (0.81-1.18)	0.961	1.01 (0.58-1.76)	0.793	0.97 (0.80-1.19)
rs17127107	0.463	1.05 (0.92-1.20)	0.771	0.484	1.00 (0.84-1.20)	1.12 (0.82-1.53)	0.811	1.02 (0.86-1.22)	0.471	1.12 (0.83-1.51)	0.862	0.98 (0.83-1.17)
rs10889502	0.394	1.06 (0.93-1.21)	0.483	0.406	1.12 (0.93-1.34)	1.11 (0.83-1.48)	0.231	1.11 (0.93-1.33)	0.733	1.05 (0.80-1.38)	0.332	1.09 (0.92-1.30)
rs7849191	0.948	1.00 (0.88-1.13)	0.963	0.910	0.98 (0.81-1.18)	1.01 (0.76-1.33)	0.852	0.98 (0.82-1.18)	0.882	1.02 (0.79-1.32)	0.774	0.97 (0.82-1.16)
rs9891119	0.459	1.05 (0.93-1.19)	0.734	0.580	1.07 (0.87-1.31)	1.10 (0.85-1.41)	0.450	1.08 (0.89-1.30)	0.644	1.05 (0.85-1.31)	0.752	1.03 (0.86-1.22)
rs4767860	0.335	1.07 (0.94-1.21)	0.604	0.511	1.05 (0.87-1.26)	1.16 (0.87-1.55)	0.461	1.07 (0.90-1.27)	0.383	1.13 (0.86-1.49)	0.863	1.02 (0.85-1.21)
rs2970847	0.835	1.02 (0.88-1.17)	0.950	0.893	1.03 (0.85-1.24)	0.99 (0.69-1.42)	0.820	1.02 (0.86-1.22)	0.921	0.98 (0.69-1.40)	0.762	1.03 (0.86-1.23)
rs6821591	0.784	0.98 (0.86-1.12)	0.670	0.634	0.93 (0.77-1.11)	1.02 (0.76-1.38)	0.532	0.95 (0.79-1.13)	0.682	1.06 (0.80-1.41)	0.372	0.92 (0.78-1.10)
rs249429	0.514	1.05 (0.91-1.22)	0.831	0.782	1.05 (0.87-1.27)	1.09 (0.73-1.63)	0.551	1.06 (0.88-1.26)	0.741	1.07 (0.72-1.59)	0.641	1.04 (0.87-1.26)
rs3805486	0.873	0.99 (0.86-1.14)	0.611	0.462	1.06 (0.88-1.27)	0.88 (0.61-1.28)	0.752	1.03 (0.86-1.23)	0.434	0.86 (0.60-1.24)	0.471	1.07 (0.89-1.28)
rs1342382	0.643	0.97 (0.84-1.11)	0.604	0.611	0.92 (0.77-1.11)	1.07 (0.74-1.54)	0.491	0.94 (0.79-1.12)	0.602	1.10 (0.77-1.58)	0.344	0.92 (0.77-1.10)
rs6588640	0.468	0.95 (0.83-1.09)	0.660	0.560	0.94 (0.78-1.13)	0.87 (0.61-1.25)	0.422	0.93 (0.78-1.11)	0.521	0.89 (0.63-1.27)	0.623	0.96 (0.80-1.14)
rs6937	0.208	1.08 (0.96-1.23)	0.421	0.380	1.14 (0.93-1.39)	1.14 (0.88-1.47)	0.190	1.14 (0.94-1.38)	0.684	1.05 (0.84-1.30)	0.390	1.08 (0.91-1.28)
rs3766522	0.209	1.13 (0.93-1.37)	0.481	0.664	1.13 (0.92-1.40)	1.17 (0.53-2.60)	0.232	1.14 (0.92-1.40)	0.752	1.14 (0.51-2.52)	0.250	1.13 (0.91-1.40)
rs10783299	0.479	0.96 (0.85-1.08)	0.790	0.462	0.94 (0.76-1.15)	0.93 (0.72-1.19)	0.492	0.93 (0.77-1.13)	0.753	0.97 (0.78-1.19)	0.722	0.97 (0.81-1.15)
rs5017427	0.121	0.90 (0.79-1.03)	0.314	0.25	0.90 (0.75-1.08)	0.81 (0.59-1.11)	0.172	0.88 (0.74-1.05)	0.292	0.85 (0.62-1.15)	0.434	0.93 (0.78-1.11)
rs9648724	0.953	1.00 (0.87-1.16)	0.971	0.883	1.01 (0.84-1.22)	0.97 (0.65-1.45)	0.921	1.01 (0.85-1.20)	0.864	0.97 (0.65-1.43)	0.863	1.02 (0.85-1.22)
rs645163	0.585	1.04 (0.92-1.17)	0.790	0.552	0.99 (0.81-1.20)	1.07 (0.83-1.38)	0.913	1.01 (0.84-1.22)	0.501	1.08 (0.86-1.35)	0.672	0.96 (0.81-1.15)
rs6436094	0.970	1.00 (0.88-1.13)	0.794	0.830	0.95 (0.78-1.16)	1.01 (0.79-1.30)	0.714	0.97 (0.80-1.16)	0.682	1.05 (0.84-1.30)	0.504	0.94 (0.79-1.12)
rs6713532	0.953	1.00 (0.88-1.14)	0.822	0.713	0.96 (0.79-1.17)	1.04 (0.79-1.35)	0.811	0.98 (0.81-1.18)	0.633	1.06 (0.84-1.34)	0.571	0.95 (0.80-1.13)
rs16147	0.348	0.94 (0.83-1.07)	0.170	0.091	1.13 (0.94-1.37)	0.77 (0.58-1.01)	0.702	1.04 (0.87-1.23)	0.012	0.72 (0.56-0.93)	0.035	1.21 (1.01-1.44)