Ability of Procalcitonin and C-Reactive Protein for Discriminating between Bacterial and Enteroviral Meningitis in Children Using Decision Tree

Table 4

Validation of clinical and laboratory parameters in bacterial meningitis prediction.

Parameters	Threshold	Direction		Sens	Spec	PPV	NPV	Acc
Procalcitonin in blood (ng/mL)	0.16	>	216	0.990	0.983	0.980	0.991	0.986
CRP in blood (mg/L)	31.2	>	216	0.939	0.974	0.969	0.950	0.958
Glucose in CSF (mmol/L)	2.2	<=	216	0.848	0.949	0.933	0.881	0.903
Neutrophils in CSF (10^6/L)	64	>	216	0.980	0.726	0.752	0.977	0.843
WBC in CSF (10^9/L)	513	>	216	0.818	0.872	0.844	0.850	0.847
Temperature (°C)	38.4	>	216	0.909	0.752	0.756	0.907	0.824
Protein in CSF (g/L)	0.3	>	216	0.949	0.709	0.734	0.943	0.819
WBC in blood (10^9/L)	12.5	>	216	0.879	0.769	0.763	0.882	0.819
Headache	Yes	=	216	0.838	0.701	0.703	0.837	0.764
Age (months)	85	≤	216	0.949	0.470	0.603	0.917	0.690
Kernig’s sign	Positive	=	216	0.838	0.538	0.606	0.797	0.676
Brudzinski’s sign	Positive	=	216	0.424	0.949	0.875	0.661	0.708
Neutrophils in blood (%)	73	>	216	0.879	0.453	0.576	0.815	0.648
ESR in blood (mm/H)	11	>	216	0.859	0.462	0.574	0.794	0.644
Haemoglobin in blood (g/L)	113	≤	216	0.576	0.744	0.655	0.674	0.667
Spasms	Single	=	216	0.212	1.000	1.000	0.600	0.639
Drowsiness	Yes	=	216	0.232	0.957	0.821	0.596	0.625
Platelets in blood (10^9/L)	252	>	216	0.545	0.607	0.540	0.612	0.579
Consciousness	Nonnormal	=	216	0.111	1.000	1.000	0.571	0.593
Gender	M	=	216	0.566	0.444	0.463	0.547	0.500

Abbreviations: sens: sensitivity; spec: specificity; ppv: positive predictive value; npv: negative predictive value; acc: accuracy.