Effects of Subacute Exposure of Dibutyl Phthalate on the Homeostatic Model Assessment, Thyroid Function, and Redox Status in Rats

Table 4

Effect of subacute exposure of dibutyl phthalate on thyroid hormones, oxidative stress, and energy metabolites in rats.

	Control	DBP; 10 mg/kg	DBP; 50 mg/kg	DBP 100 mg/kg	(treatment)	(linear)	(quadratic)	()
Total T3 (ng/dL)					0.10	0.71	0.19	0.38
Total T4 (μg/dL)	^a	^ab	^ab	^b	0.01	<0.01	0.90	0.21
Catalase activity (nmol/min/mL)					0.79	0.39	0.91	0.23
Malondialdehyde (nmol/mL)	^a	^ab	^ab	^b	0.01	0.01	0.56	0.66
NEFA (mmol/L)	^a	^b	^ab	^ab	0.04	0.13	0.02	0.20
β-HB (mmol/L)	^a	^b	^b	^b	< 0.01	0.03	0.10	0.24

Data are presented as . Superscripts ^a-b within the row indicate significant differences (). Two-way ANOVA was used for assessing the effects of treatment and gender. Polynomial contrasts (linear and quadratic) were used to assess monotonic and nonmonotonic responses.