Anti-Inflammatory, Antioxidant, Chemical Characterization, and Safety Assessment of Argania spinosa Fruit Shell Extract from South-Western Morocco

Figure 5

Histopathological analyses of the liver and kidney in male mice after oral administration for 28 days. Liver: A1 (control HE, 200x), B1 (AFSEE 250 mg/kg HE, 200x), C1 (AFSEE 500 mg/kg HE, 200x), D1 (AFSEE 1000 mg/kg HE, 200x), and E1 (AFSEE 2000 mg/kg HE, 200x). Kidney: A2 (control HE, 200x), B2 (AFSEE 250 mg/kg HE, 200x), C2 (AFSEE 500 mg/kg HE, 200x), D2 (AFSEE 1000 mg/kg HE, 200x), and E2 (AFSEE 2000 mg/kg HE, 200x). Sections of liver and kidney showing no significant histopathological changes after administration of AFSEE for 28 days compared to the control group ( each group).