Investigation of Hypoglycemic Peptides Derived from Conserved Regions of adMc1 to Reveal Their Antidiabetic Activities

Table 4

Pharmacokinetic parameters important for bioavailability of compounds drug-likeness properties of selected peptides.

Peptides	Target	Molecular properties^†
		MW	HBD	HBA	Nrotb	Log		Violations
SMCG	SGLT1	396.48	6	7	15	-1.86	94.77	1
DECC		468.50	7	10	17	-2.39	107.10	1
TTIT		434.48	8	9	15	-2.06	105.61	1
RTTI	GLUT2	489.57	10	9	19	-2.17	123.16	1
ARNL		472.54	9	8	19	-2.38	118.94	1
TVEV	DPP-IV	446.50	7	9	16	-0.93	109.86	1
FDEC		512.53	7	10	18	-1.40	123.66	2

^†Molecular properties were calculated using SwissADME an online tool. MW: molecular weight; HBD: number of hydrogen bond donors; HBA: number of hydrogen bond acceptors; nrotb: number of rotatable bonds; log : the logarithm of octanol/water partition coefficient; A: molar refractivity.