Investigation of Hypoglycemic Peptides Derived from Conserved Regions of adMc1 to Reveal Their Antidiabetic Activities

Table 5

ADMET profiling of best selected peptides.

	SMCG	DECC	TTIT	RTTI	ARNL	TVEV
Absorption
Blood-brain barrier	BBB+	BBB+	BBB+	BBB+	BBB+	BBB+
Human intestinal absorption	HIA-	HIA-	HIA-	HIA-	HIA+	HIA-
Caco-2 permeability	Caco-2-	Caco-2-	Caco-2-	Caco-2-	Caco-2-	Caco-2-
P-Glycoprotein substrate	Substrate	Nonsubstrate	Nonsubstrate	Nonsubstrate	Substrate	Nonsubstrate
P-Glycoprotein inhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor
Renal organic Cation transporter	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor
Metabolism
CYP3A4 substrate	Substrate	Nonsubstrate	Nonsubstrate	Nonsubstrate	Substrate	Nonsubstrate
CYP2C9 substrate	Nonsubstrate	Nonsubstrate	Nonsubstrate	Nonsubstrate	Substrate	Nonsubstrate
CYP2D6 substrate	Nonsubstrate	Nonsubstrate	Nonsubstrate	Nonsubstrate	Nonsubstrate	Nonsubstrate
CYP3A4 inhibition	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor
CYP2C9 inhibition	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor
CYP2C19 inhibition	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor
CYP2D6 inhibition	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor
CYP1A2 inhibition	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor	Noninhibitor
Toxicity
AMES toxicity	Non-AMES toxic	Non-AMES toxic	Non-AMES toxic	Non-AMES toxic	Non-AMES toxic	Non-AMES toxic
Carcinogens	Noncarcinogens	Noncarcinogens	Noncarcinogens	Noncarcinogens	Noncarcinogens	Noncarcinogens