Therapeutic Potential of RTA 404 in Human Brain Malignant Glioma Cell Lines via Cell Cycle Arrest via p21/AKT Signaling

Figure 1

RTA 404 mediates the survival of GBM8401 and U-87-MG cells by inhibiting proliferation: (a) and (b) cells were treated with increasing doses of RTA 404 for 24 h in vitro. (c)The GBM cells were cotreated with increasing doses of RTA 404 with radiation in vitro. (d) The GBM cells were cotreated with increasing doses of RTA 404 with TMZ in vitro. The survival of RTA 404-treated cancer cells was measured using the MTT assay. Results are expressed as percentage of the control, control being 100%. Statistical analysis was performed using the -test, with differences between the treatment and control groups (0 nM RTA 404) considered significant at , delineated by .

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