Therapeutic Potential of RTA 404 in Human Brain Malignant Glioma Cell Lines via Cell Cycle Arrest via p21/AKT Signaling

Figure 3

Influence of RTA 404 on invasion and adhesion ability of GBM cell lines. RTA 404 reduced the invasion ability of (a) U87 MG and (b) GBM8401 cells. (c) RTA 404 reduced the invasion ability of GBM cell lines. (d) and (e) The adhesion assay found marked inhibition of the cell lines treated with RTA 404 (500 nM) at 24 hours. RTA 404 reduced the adhesion of GBM cell lines. Statistical analysis used the -test, with significance set at for the RTA 404 0 nM group.

(a)

(b)

(c)

(d)

(e)