Therapeutic Potential of RTA 404 in Human Brain Malignant Glioma Cell Lines via Cell Cycle Arrest via p21/AKT Signaling

Figure 6

RTA 404 regulated the gene expression (N-cadherin, E-cadherin, p21, p-AKT, AKT) in GBM8401 and U-87-MG cells. Cells were treated with RTA 404 for 24 h. Gene and protein expressions were subsequently detected using Western blot analysis. Results are expressed as percentage of the control, control being 100%. Statistical analysis was performed using the -test, with differences between the treatment and control groups (0 nM RTA 404) considered significant at , delineated by .

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