Roux-en-Y Gastric Bypass Improved Insulin Resistance via Alteration of the Human Gut Microbiome and Alleviation of Endotoxemia

Figure 1

RYGB changed the composition of gut microbiota. Comparison among shotgun sequencing data of stool samples from the preop group, post-1 m-op group, post-3 m-op group, and post-6 m-op group, each group contain 14 patients. (a) The abundance of species in each group. Abundance of species belonging to the preop group was the highest in all the phases, lowest in the post-1 m-op group, recovered gradually, and approached to the preop group at post-6 m-op. (b) Canonical analysis of principal coordinates among 4 groups. There was significant difference in the component of microbiota between the preop group and postop groups and no much diversity among postop groups. (c) Indicator species in each group. Chose OTU over 0.4 as the indicator value when it exists in one group. There were more indicator species in the preop group and more “common” indicator species belonging to three postop groups contemporary.

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