Gentiopicroside Produces Endothelium-Independent Vasodilation by Deactivating the PI3K/Akt/Rho-Kinase Pathway in Isolated Rat Thoracic Aorta

<div>Effects of GPS treatment on intracellular Ca<sup>2+</sup> release. (a) Endothelium-denuded aortic rings were precontracted with PE, (b) narciclasine, and (c) phorbol-12,13-diacetate (PD), followed by GPS (20, 80, and 160 <i>μ</i>M) treatment and detection of the vasorelaxation of the rings in Ca<sup>2+</sup>-free Krebs solution. (d) Endothelium-denuded aortic rings were incubated with ruthenium red and heparin in Ca<sup>2+</sup>-free Krebs solution, and then, the rings were treated with GPS (20, 80, and 160 <i>μΜ</i>) after precontracted with PE. 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BioMed Research International

fig6

Figure 6

Figure 6: Gentiopicroside Produces Endothelium-Independent Vasodilation by Deactivating the PI3K/Akt/Rho-Kinase Pathway in Isolated Rat Thoracic Aorta 

Figure 6 | Gentiopicroside Produces Endothelium-Independent Vasodilation by Deactivating the PI3K/Akt/Rho-Kinase Pathway in Isolated Rat Thoracic Aorta 